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Frame Overo Lethal White Syndrome (OLWS) is a lethal condition associated with the frame overo or overo white spotting pattern.
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Caractéristiques
| Breeds | Cheval miniature, Paint horse américain, Pur sang, Quarter Horse américain, Falabella, Pinto Horse |
|---|---|
| Gene | |
| Organ | |
| specimen | Hair, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Frame Overo Lethal White Syndrome (OLWS) is a lethal condition associated with the frame overo or overo white spotting pattern. It is an incompletely dominant inherited syndrome seen in foals born to parents with the frame overo coat-pattern lineage. The frame overo pattern can vary widely, ranging from horses with very minimal white markings to those with extensive white. This condition is linked to a mutation in the endothelin B receptor gene (EDNRB), which plays a critical role in the proper development of both pigment and nerve cells during development of the embryo.
Caractéristiques cliniques
Foals affected by OLWS are typically born with an almost completely white coat and striking blue eyes. Although they may appear healthy at birth, they suffer from an underdeveloped intestinal tract. This condition quickly leads to severe colic and, tragically, often results in death within a few days after birth, as there is currently no effective treatment.
Foals that inherit two copies of the mutation will be affected by the lethal condition. Horses that inherit only one copy of the mutation typically display the frame overo coat pattern and do not suffer from intestinal issues. However, they may be at risk for deafness.
Additional Information
Références
Pubmed ID: 9530628
Omia ID: 629