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Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 18 |
| Mutation | c.538G>C |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Also known as | LEMP |
Informations générales
Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination. The disorder is caused by a recessive mutation to the gene NAPEPLD. The variant of LEMP analysed in this test occurs in the Leonberger. A related variant is found in the Great Dane and Rottweiler.
Caractéristiques cliniques
Onset of LEMP symptoms in affected dogs generally occurs between 1 and 2 years of age. Signs include ataxia (loss of coordination), knuckling and dragging of the paws, hypermetria (overextension of limbs while stepping) and reduced spinal reflexes. The disease progresses over a matter of months, and euthanasia on humane grounds is likely to be considered.
Additional Information
Références
Pubmed ID: 29643404
Year published: 2018
Omia ID: 1788
Omia variant ID: 985