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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 10 |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Also known as | Wilson disease |
Informations générales
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
While copper toxicosis also occurs in breeds such as the Doberman and Labrador Retriever, the disorder in those breeds is caused by a mutation to another gene, ATP7B.
Caractéristiques cliniques
Clinical signs of liver damage as a result of copper toxicosis can include an inflamed liver, anorexia, vomiting, lethargy, weight loss, jaundice and a swollen abdomen.
Copper toxicosis can be mitigated with a low-copper, high-zinc specialized diet.
Additional Information
Avec les rapports actuels on ne peut pas affirmer que la suppression dans le gène COMMD1 est la seule cause de la toxicose de cuivre.
Références
Pubmed ID: 16293123
Year published: 2005
Omia ID: 1988
Omia variant ID: 643