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Primary Open Angle Glaucoma (POAG) is an eye disorder that builds up pressure in the eye and affects the nerves of the retina, damaging vision.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 3 |
| Mutation | c.1552G>A |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Also known as | POAG |
Informations générales
Primary Open Angle Glaucoma (POAG) is an eye disorder that builds up pressure in the eye and affects the nerves of the retina, damaging vision. This variant of the disease, caused by a recessive mutation to the gene ADAMTS17, occurs in the Basset Fauve de Bretagne. Similar variants also occur in the Basset Hound, Petit Basset Griffon Vendéen, and Chinese Shar-Pei/Shar Pei/Sharpei.
Caractéristiques cliniques
Affected dogs experience a progressive increase of pressure in the eyes (intra-ocular pressure, IOP), which becomes apparent around 5 years of age. Signs can include excessive squinting, blinking, tearing and redness of the eyes. If left untreated, the disease will result in a gradual loss of vision.
Additional Information
Références
Pubmed ID: 26474315
Year published: 2015
Omia ID: 1976
Omia variant ID: 96