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Dilated Cardiomyopathy (DCM) is a heart disorder characterised by enlargement of the heart (especially of the left ventricle), poor myocardial contractility, and congestive heart failure.
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Caractéristiques
| Breeds | Manchester Terrier (Standard), Manchester Terrier (Toy), English Toy Terrier |
|---|---|
| Gene | |
| Chromosome | 27 |
| Mutation | c.3557G>A |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Also known as | JDCM |
Informations générales
Dilated Cardiomyopathy (DCM) is a heart disorder characterised by enlargement of the heart (especially of the left ventricle), poor myocardial contractility, and congestive heart failure. This variant of the disorder, known as Juvenile Dilated Cardiomyopathy (JDCM), occurs in young dogs of the Manchester Terrier and English Toy Terrier breeds. It is caused by a recessive disorder to the gene ABCC9. The disorder is severe, and can cause sudden death of juvenile affected dogs.
Caractéristiques cliniques
Signs of congestive heart failure caused by DCM in affected dogs can include rapid or strained breathing while resting, restlessness, general weakness, decreased appetite and vomiting, pale gums and sudden death. Veterinary examination can provide a proper diagnosis. JDCM occurs in juvenile dogs, often before the age of 2 years.
Additional Information
Références
Pubmed ID: 37239348
Year published: 2023
Omia ID: 2710
Omia variant ID: