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Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | C1 |
| Mutation | c.937C>T |
| Mode of Inheritance | Autosomique dominante |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Also known as | DBE |
Informations générales
Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris. It is often due to genetics and is commonly seen in certain breeds. One of the genes involved in this trait is the Paired Box 3 (PAX3) gene. Mutations in the gene can result in white spotting, deafness, pigmentary disturbances in one or two eyes. Homozygosity for this mutation will most likely lead to embryonic or fetal lethality.
There are multiple mutations known. The variant tested here is found in Maine Coon cats and is know as DBE-RE.
Caractéristiques cliniques
Cats with this mutation show one or two blue or particoloured eyes and minimal white spotting. This does not necessarily indicate any underlying health issues. In different feline breeding lines deafness has been identified as being associated with this mutation.
Additional Information
The mating of two heterozygous cats is not recommended in order to prevent the production of homozygous kittens, which mutation will most likely lead to embryonic or fetal lethality.
Additionally, mating a carrier with a non-carrier animal is not recommended, as it can result in the birth of blue-eyed, deaf kittens associated with this variant.
Références
Pubmed ID: 38869246
Year published: 2024
Omia ID: 1688
Omia variant ID: