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The gene TRYP1 is known as the Brown Locus (B-Locus), and is one of the main genes responsible for different coat colours in dogs.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 11 |
| Mutation | c.125G>A |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Also known as | B-Locus |
Informations générales
The gene TRYP1 is known as the Brown Locus (B-Locus), and is one of the main genes responsible for different coat colours in dogs. Dogs affected by a mutation to the B-Locus have altered pigment production, resulting in a brown coat instead of black. There are several different known variants of this mutation. This particular variant, known as b^h, is specific to the Siberian Husky. The mutation is recessive.
Caractéristiques cliniques
Dark-coated dogs affected by a B-Locus mutation have a brown coat instead of black. Depending on the breed, this coat colour can be described as brown, chocolate, liver or red. Affected dogs also have brown noses and paw pads.
Additional Information
Coat colour is an complex trait that relies on the interaction of many different genes. Several different tests may be required to form the most accurate image of an animal's coat colour genetics.
Références
Pubmed ID: 33421162
Year published: 2021
Omia ID: 1249
Omia variant ID: 1282