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Coat colour in dogs is controlled by a wide range of different genes working together.
10 working days
Caractéristiques
Breeds | Chien de berger des Shetland, Lévrier greyhound, Mastiff anglais, Mudi, Pékinois, Petit lévrier italien, Pumi, Dogue du Tibet, Chihuahua, Shih-Tzu, Yorkshire Terrier |
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Gene | |
Organ | |
specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
Mode of Inheritance | |
Chromosome | |
Also known as | |
Year Published |
Informations générales
Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Dilution, or D-Locus, corresponds to the gene for melanophilin, MLPH, which is involved in the distribution of pigment. Mutations of the D-Locus result in a ‘dilution’ of dark coat colours, turning them lighter and more silvery.
Any combination of two mutant alleles will result in a diluted coat. This variant of the D-Locus mutation, designated as d^3, is found in breeds such as the Chihuahua, Hungarian Mudi and Hungarian Pumi, Italian Greyhound and Shih-Tzu.
Caractéristiques cliniques
La couleur des cheveux et du nez est diluée, la couleur des yeux s’éclaircit en ambre. L’allèle D est dominant et n’a pas d’effet sur la couleur du pelage. Ce n’est que chez les chiens avec deux copies d’un allèle récessif d que la couleur du pelage est diluée. Le noir se dilue en gris, également appelé bleu ou charbon de bois. Le pelage varie de l’argent à presque noir, mais tous ont le nez bleu. Chocolat / brun / foie se dilue en lilas / bronzage clair / Isabella, leur nez varie de rose, foie à isabelle. Rouge/jaune/crème se dilue en champagne.
Additional Information
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
Additional, undiscovered variants of the D-Locus mutation are likely to exist.
Références
Pubmed ID: 32531980
Omia ID: 31