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H821

Coat colour in dogs is controlled by a wide range of different genes working together.

10 working days

Caractéristiques

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

Informations générales

Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The I-Locus, a.k.a intensity dilution/intensity/ dilution, corresponds to the gene MFSD12, which is involved in pigment production and distribution. A dominant mutation to this gene, designated as I, further dilutes the phaeomelanin (light pigment) of affected dogs, which can lighten a yellow or red coat to cream or white. The unaffected recessive allele, designated as i, results in normal coloration.

Caractéristiques cliniques

Affected dogs (I/I or I/i) develop lightened coats (usually described as pale cream or white), as long as they are also affected by the recessive variant of the E-Locus (e/e). Affected dogs are not albino, and should retain a dark coloration of the lips, paw pads, eye rims, etc.

Likewise, dogs with a black-and-tan or saddle tan phenotype will display creamy instead of tan fur.

Additional Information

Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.

Références

Pubmed ID: 31117290

Omia ID: 2197

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