Cystinuria – English and French Bulldog

Cystinuria is a genetic disorder that leads to recurrent urolith formation. The disorder is associated with a mutation in the SLC7A9 gene. The mutation causes hyperexcretion of cystine in the urine and sebsequent precipitation of cystine.

Clinical signs include cystine stones in the kidneys, ureters, and bladder. Once a stone is formed, the following signs and symptoms can occur nausea, flank pain, urinary tract infections and rarely, acute or chronic kidney disease.