57,48 47,50 hors TVA

K385

Blood coagulation or blood clotting, is an important process to stop the bleeding at a wound site.

10 working days

Excl €5,95 shipping and administration per order (incl. VAT)

Caractéristiques

Breeds

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Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Year Published

Informations générales

Blood coagulation or blood clotting, is an important process to stop the bleeding at a wound site. This process is mediated by multiple factors contributing to the coagulation cascade. One of these factors is plasma coagulation factor XII (factor 12, FXII or F12).

This test detects a DNA variant that is associated with a severe decrease in FXII activity causing difficulties in blood coagulation. It is found in several breeds, thoug is less widespread as the other variant offered.

Caractéristiques cliniques

This variant leads to FXII deficiency, resulting in the absence of detactable factor XII in the cat's blood plasma. Cats homozygous for this mutation have a severe deficiency and will likely have an increased tendency to bleeding after surgery or (minor) trauma. Cats that are heterozygous have a moderate reduction in FXII activity.

Additional Information

In literature an autosomal recessive inheritance pattern is suggested, but also describes mild clinical features in cats heterozygous for this variant.

Références

Pubmed ID: 24793828

Omia ID: 364

Comment ça marche?

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2. Prélevez un échantillon d’ADN

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3. Résultat

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