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K390

In the Birman cat breed, a hereditary disorder has been observed that results in hypotrichosis (loss of hair) and thymic aplasia (an underdeveloped thymus), resulting in a drastically lowered life expectancy.

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Caractéristiques

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Year Published

Informations générales

In the Birman cat breed, a hereditary disorder has been observed that results in hypotrichosis (loss of hair) and thymic aplasia (an underdeveloped thymus), resulting in a drastically lowered life expectancy. The disorder is caused by a recessive mutation to the gene FOXN1.

Caractéristiques cliniques

Affected kittens are born hairless, and only develop a sparse and shortened coat, as well as wrinkled and greasy-seeming skin. They are prone to infections of the airways, digestive system and skin. Survival past the age of 8 months is unlikely, and euthanasia on humane grounds is likely to be considered.

Additional Information

Références

Pubmed ID: 25781316

Omia ID: 1949

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