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H708

Canine Spongiform Leukoencephalomyelopathy (SLEM), also known as simply Leukodystrophy, is a severe degenerative neurological disease that causes weakness, paralysis and spastic movement.

10 working days

Caractéristiques

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Year Published

Informations générales

Canine Spongiform Leukoencephalomyelopathy (SLEM), also known as simply Leukodystrophy, is a severe degenerative neurological disease that causes weakness, paralysis and spastic movement. The disorder is caused by a mitochondrial mutation to the gene CYTB, and is found in the Australian Cattle Dog and the Shetland Sheepdog.

Caractéristiques cliniques

Affected puppies usually begin presenting with whole-body tremors at approximately 3 to 4 weeks of age. They are initially able to walk, but progressively lose coordination over several weeks of development. Other symptoms include spastic twitches of the limbs, jaw drop, difficulty swallowing, excessive salivation, failure to grow and an inability to walk. The disease is progressive, and affected dogs are typically euthanized on humane grounds.

Additional Information

Références

Pubmed ID: 16026996

Omia ID: 2684

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