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H864

The Lundehund breed is predisposed to Lundehund Syndrome (LS), a unique gastro-intestinal disease.

10 working days

Caractéristiques

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

Informations générales

The Lundehund breed is predisposed to Lundehund Syndrome (LS), a unique gastro-intestinal disease. Lundehund Syndrome varies in severity, ranging from minor recurrent diarrhea to severe inflammation resulting in death or necessitating euthanasia on humane grounds. It can be partially treated with anti-inflammatory drugs, specialized diets and vitamin supplements.

While the precise cause of the disease is still being studied, it is in part associated with a recessive defect to the gene P3H2 (also known as LEPREL1).

Caractéristiques cliniques

Onset of Lundehund Syndrome symptoms varies, but is usually between 2 and 10 years of age. Symptoms are diarrhea, vomiting, weight loss and hair loss, edema of the limbs, ascites and/or lethargy. Affected dogs’ blood profiles show decreased albumin and globulin.

Additional Information

The mutation in this test should be considered a risk factor. It is associated with the disorder, but does not necessarily guarantee it.

Références

Pubmed ID: 27485430

Omia ID: 2031

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