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May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts.

10 working days

Caractéristiques

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

Informations générales

May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts. This variant of the disease, caused by a dominant mutation to the gene MYH9, has been observed in the Pug.

Caractéristiques cliniques

Affected dogs display thrombocytopenia (lowered blood platelet counts), but might not necessarily develop any bleeding problems. Additionally, an affected dog may develop skin lesions and white plaques in the mouth following immunosuppressive treatment.

Additional Information

Références

Pubmed ID: 21554370

Omia ID: 1608

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