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Multi Drug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | A2 |
| Mutation | c.1930_1931delTC |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Also known as | MDR1 |
Informations générales
Multi Drug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier. As a result, affected animals can be in effect poisoned when given certain drugs as part of standard veterinary procedures. In cats, a variant of the disease is caused by a recessive mutation to the gene ABCB1.
It is estimated that this mutation occurs in approximately 4% of domestic cats.
Caractéristiques cliniques
Affected cats are likely to experience adverse reactions (central nervous system toxicity) to P-glycoprotein substrate drugs such as ivermectin, imidacloprid and selamectin.
Additional Information
Références
Pubmed ID: 25660379
Year published: 2015
Omia ID: 1402
Omia variant ID: