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The enzyme CYP1A2 is involved in metabolism; the body’s system for processing chemical compounds.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 30 |
| Mutation | c.1117C>T |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
Informations générales
The enzyme CYP1A2 is involved in metabolism; the body’s system for processing chemical compounds. Research has shown that certain Beagles are affected by a recessive mutation to the CYP1A2 gene, leaving them less able to process certain specific drugs such as the memory-enhancing compound AC-3933.
Caractéristiques cliniques
Affected dogs have a decreased functionality of the CYP1A2 enzyme, processing certain drugs differently, but are expected to appear mostly normal and healthy.
Additional Information
Références
Pubmed ID: 15564884
Year published: 2004
Omia ID: 1405
Omia variant ID: 274