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Prekallikrein deficiency (PK or KLK) is an uncommon disorder in dogs caused by a mutation in the KLKB1 gene.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Informations générales
Prekallikrein deficiency (PK or KLK) is an uncommon disorder in dogs caused by a mutation in the KLKB1 gene.
Caractéristiques cliniques
Les symptômes incluent une suspicion d'anomalies neurologiques et un temps de thromboplastine partielle activée activée (aPTT) et un temps de prothrombine (PT) normal sans anomalies hémostatiques.
Additional Information
PK and FXII deficiency are known to interact with each other, leading to acceleration of contact phase activation. Which indicates that simultaneous deficiency of both factors could cause the clinical symptoms, even when sole deficiency of FXII or PK does not show any symptoms.
Références
Pubmed ID: 20736516
Omia ID: 819