Dominant Blue Eyes Celestial (DBE-CEL)

This test is temporarily unavailable.At this point the possibility of false-positive results cannot be excluded. We are in contact with the study’s author to verify the reliability of this test before offering it commercially again. For this reason, the test is temporarily unavailable.Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris. It is often due to genetics and is commonly seen in certain breeds. One of the genes involved in this trait is the Paired Box 3 (PAX3) gene. Mutations in the gene can result in white spotting, deafness, pigmentary disturbances in one or two eyes and in some cases also embryonic or fetal lethality. The tested mutation for the Celestial line is characterised by an autosomal dominant inheritance with variable expressivity and incomplete penetrance for both white spotting and blue eyes.

There are multiple mutations known. The variant tested here is found in the Celestial Maine Coon line, Siberian and Celestial cats and is also know as DBE-CEL.