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Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs.
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Caractéristiques
| Breeds | Biewer Terrier, Chien de berger des Shetland, Huntaway, New Zealand Heading Dog, Norwegian Lundehund, Poodle (Standard), Schnauzer (Standard), Belgian Malinois, Beagle, Cocker Spaniel, Rottweiler, Shih-Tzu, Yorkshire Terrier |
|---|---|
| Organ | |
| Gene | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomique dominante |
| Chromosome | 16 |
Informations générales
Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs. Specifically, polydactyly restores the first toe that was lost over the course of the evolution of the wolf, giving affected dogs a fifth toe known as a “dewclaw”. This specific variant (DC-2) is caused by a dominant mutation to the Limb Development Membrane Protein 1 (LMBR1) gene that affects the expression of the sonic hedgehog (SHH) gene.
This test measures the mutation known as DC-2. Another mutation, DC-1, is found in Sapsari and Tosa dogs.
Caractéristiques cliniques
Affected dogs develop an extra toe, or dewclaw, on their hind legs.
Additional Information
Références
Pubmed ID: 18689889
Year published: 2008
Omia ID: 810
Omia variant ID: