€57,48 €47,50 hors TVA
Canine Leukocyte Adhesion Deficiency (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies.
10 working days
Excl €5,95 shipping and administration per order (incl. VAT)
Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 18 |
| Mutation | c.1349_1350insAAGACGGCTGCC |
| Mode of Inheritance | Autosomique récessif |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Also known as | LAD3 |
Informations générales
Canine Leukocyte Adhesion Deficiency (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies. This variant of the disease, CLAD Type III, is caused by a recessive mutation in FERMT3, which causes malfunctioning of white blood cells and platelets. The variant is found in the German Shepherd.
Caractéristiques cliniques
In dogs that suffer of Canine Leucocyte Adhesion Deficiency type III, the healing capacities are impaired. Affected dogs are highly vulnerable to infection. They are likely to die early in life from multiple severe infections, even if treated with massive doses of antibiotics.
Additional Information
Références
Pubmed ID: 20126836
Year published: 2010
Omia ID: 1525
Omia variant ID: 576