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Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull.
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Caractéristiques
| Breeds | Terrier blanc des Highlands de l’Ouest, Terrier écossais, Cairn Terrier |
|---|---|
| Gene | |
| Chromosome | 5 |
| Mutation | c.1332C>T |
| Mode of Inheritance | Autosomal dominant with incomplete penetrance |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Also known as | CMO |
Informations générales
Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull. Occurring in West Highland White Terriers, Scottish Terriers and Cairn Terriers, it is caused by a dominant mutation with incomplete penetrance to the Solute Carrier Family 37 Member 2 (SLC37A2) gene.
Because of its occurance in the West Highland White Terrier, the disorder is also known as Westie Jaw.
A closely related variant of the disorder is found in the Basset Hound.
Caractéristiques cliniques
CMO begins manifesting in affected dogs between 4 and 8 months of age. Signs include swelling of the jaw, difficulty opening the jaw, pain, a lack of apetite and periodic fever. Bony lesions develop on the skull, mainly on the jawbone. Symptoms usually recede when the dog has finished its growth period.
Additional Information
Références
Pubmed ID: 27187611
Year published: 2016
Omia ID: 2244
Omia variant ID: 411