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Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a skeletal disorder that generally occurs in young, growing dogs under 1 year old, and causes painful growth of the jawbone.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 5 |
| Mutation | c.1446+1G>A |
| Mode of Inheritance | Autosomal dominant with incomplete penetrance |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Also known as | CMO |
Informations générales
Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a skeletal disorder that generally occurs in young, growing dogs under 1 year old, and causes painful growth of the jawbone. It is caused by a dominant mutation with incomplete penetrance to the Solute Carrier Family 37 Member 2 (SLC37A2) gene.
The variant analysed in this test occurs in the Basset Hound. A related variant has been observed in the Cairn Terrier, Scottish Terrier and West Highland White Terrier.
Caractéristiques cliniques
The main symptom of CMO is painful swelling of the lower jaw caused by bone growth. The discomfort caused by the swelling may in turn cause difficulty opening the mouth, excessive salivation, reduced appetite and possible malnutrition. Additionally, the inflammation of tissue around the jaw may cause fever. Symptoms usually resolve and disappear after the dog grows to adulthood.
Additional Information
Références
Pubmed ID: 32033218
Year published: 2020
Omia ID: 2244
Omia variant ID: 1158