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H901

Craniomandibular Osteopathy (CMO) is a skeletal disorder that generally occurs in young, growing dogs under 1 year old, and causes painful growth of the jawbone.

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Caractéristiques

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

Informations générales

Craniomandibular Osteopathy (CMO) is a skeletal disorder that generally occurs in young, growing dogs under 1 year old, and causes painful growth of the jawbone. It is caused by an incompletely penetrant dominant mutation to the gene SLC37A2. The variant analysed in this test occurs in the Basset Hound. A related variant has been observed in the Cairn Terrier, Scottish Terrier and West Highland White Terrier.

Caractéristiques cliniques

The main symptom of CMO is painful swelling of the lower jaw caused by bone growth. The discomfort caused by the swelling may in turn cause difficulty opening the mouth, excessive salivation, reduced appetite and possible malnutrition. Additionally, the inflammation of tissue around the jaw may cause fever. Symptoms usually resolve and disappear after the dog grows to adulthood.

Additional Information

Références

Pubmed ID: 32033218

Omia ID: 2244

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