57,48 47,50 hors TVA

H746

Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia.

10 working days

Excl €5,95 shipping and administration per order (incl. VAT)

Caractéristiques

Breeds

, , , ,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

Informations générales

Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia. It typically remains unnoticed unless triggered, most often by certain anesthetic drugs. When activated, it can cause a rapid and severe reaction involving abnormal muscle activity and dangerously accelerated metabolism. MH is caused by a mutation in the RYR1 gene and is inherited in an autosomal dominant manner. This mutation has been identified in several breeds, including Doberman, Labrador Retriever, Rough Collie, Smooth Collie and German Shepherd.

Caractéristiques cliniques

Dogs with MH generally appear completely healthy until exposed to a triggering factor, such as specific anesthetic agents. When triggered, symptoms may develop within minutes and include extremely high body temperature, muscle stiffness, rapid breathing, irregular heart rhythm, and collapse. The reaction is rapid and can be life-threatening without the immediate discontinuation of the anesthetic and emergency care. MH can occur at any age, but clinical signs are most often seen during surgical procedures involving general anesthesia.

Additional Information

Références

Pubmed ID: 11575546, 15474681

Omia ID: 621

Comment ça marche?

1. Sélectionnez vos produits

Sélectionnez un seul test, un package CombiBreed ou créez votre propre package.

2. Prélevez un échantillon d’ADN

Prélevez le matériel d’ADN comme indiqué avec nos produits et envoyez-le au laboratoire.

3. Résultat

Nous traitons votre commande avec soin et vous communiquons les résultats.