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Multidrug resistance 1 (MDR1), also called Ivermectin Sensitivity, is a defect in the blood-brain barrier that can cause an adverse reaction to certain drugs.
10 working days
Caractéristiques
| Breeds | Berger allemand, Berger australien, Bobtail, Chien de berger des Shetland, Collie à poil court, Collie rugueux, Lévrier whippet, Border Collie |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Multidrug resistance 1 (MDR1), also called Ivermectin Sensitivity, is a defect in the blood-brain barrier that can cause an adverse reaction to certain drugs. It is caused by a mostly recessive mutation to the ABCB1 (MDR1) gene.
Caractéristiques cliniques
La neurotoxicité après l’administration du médicament, qui varie en fonction de la dose, est le signe principal. Les chiens peuvent présenter une ataxie, des tremblements, des convulsions, une salivation excessive, une obtundation, une bradycardie, une mydriase, une perte de menace, une perte de réponses à la lumière papillaire, un coma et un arrêt respiratoire.
Additional Information
This test is based on an association study.
This disorder is noted as recessive. However, in some cases, carriers of the mutation have been observed to present with a milder form of the disorder.
Références
Pubmed ID: 11692082
Omia ID: 1402
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H869
Fecundity
- Entlebucher Mountain Dog
- GDF9
- Système reproducteur
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- Border Collie
- ABCB1
- Système nerveux
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- Shetland Sheepdog
- BBS2
- Organes sensoriels
