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Intervertebral disc disease (IVDD) is a degenerative condition.
10 working days
Caractéristiques
| Breeds | Bichon havanais, Bouledogue Français, Caniche miniature, Cardigan Gallois Corgi, Chinois à crête, Cocker américain, Dandie Dinmont Terrier, Épagneul Springer anglais, Pékinois, Poodle (Toy), Retriever de la baie de Chesapeake, Retriever de la Nouvelle-Écosse, Teckel, Terrier écossais, Basset Hound, Beagle, Cavalier King Charles Spaniel, Chihuahua, Coton de Tulear, Jack Russell Terrier, Shih-Tzu |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Intervertebral disc disease (IVDD) is a degenerative condition. The disease causes burstings into the spinal cord between the bones of the spinal column. The disorder is caused by a complex mutation, a FGF4 retrogene insertion, on chromosome 12.
Caractéristiques cliniques
Clinical features include abnormal walking, hunched back or neck with tense muscles, paralysis and reduced appetite and activity level.
Additional Information
The occurrence of this genetic variant in some breeds is high but it is known that not all dogs that carry the 12-FGF4RG variant will develop IVDD and vice versa. This suggests that this variant is not ‘the whole story’ and there are almost certainly additional lifestyle and/or genetic risk factors for IVDD that remain to be identified.
Références
Pubmed ID: 29073074
Omia ID: 157
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