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Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene. Animals with the disease show degeneration of sensory nerve cells and motor nerve cells.
This variant is for the Border Collie.
Caractéristiques cliniques
The first clinical signs of SN present between 2 and 7 months of age. The first visible signs are progressive proprioceptive ataxia with intermittent "knuckling" of the paws, hyperextension of the limbs, and self-mutilation wounds on and around the paws. Generally, the hind limbs are more severely affected than the front limbs. Later stages can also involve loss of sensation, and urinary incontinence.
Additional Information
D’autres races ou des races mixtes avec des ancêtres border collie peuvent également être affectées.
Références
Pubmed ID: 27527794
Omia ID: 2032